ZA loops of bromodomains

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Reexamination Certificate

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Reexamination Certificate

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07919276

ABSTRACT:
The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides a binding partner for the bromodomain. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.

REFERENCES:
patent: 5858686 (1999-01-01), Schlessinger et al.
patent: 0124221 (1984-11-01), None
patent: WO 98/03652 (1998-01-01), None
Haynes et al., “The bromodomain: a conserved sequence found in human,Drosophilaand yeast proteins,” Nucleic Acids Research, vol. 20 No. 10, p. 2603 (May 1992).
Archer and Hodin, Curr. Opin. Genet. Biol., 9: 171-74, 1999.
Carson, J. Appl. Crystallogr, 24: 958-61, 1991.
Dhalluin et al., Nature, 399: 491-96, 1999.
Grunstin, Nature, 389: 349-52, 1997.
Jacobson and Pillus, Curr. Opin. Genet. Biol., 9: 175-84, 1999.
Jeanmougin et al., Trends in Biochemical Sciences, 22: 151-53, 1997.
Kiernan et al., EMBO Journal, 18: 6106-118, 1999.
Shuker et al., Science, 274: 1531-34, 1996.
Sobulo et al., PNAS USA, 94: 8732-37, 1997.
Struhl, Genes Dev., 12: 599-606, 1998.
Zhou et al., J. Biol. Chem., 270: 31119-31123, 1995.

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