Z-benzylidene-tetrahydroquinolines and analogues thereof

Details Z-benzylidene-tetrahydroquinolines and analogues thereof Z-benzylidene-tetrahydroquinolines and analogues thereof

1995-04-18

1997-02-18

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546112, A61K 3147, C07D21516

Patent

active

056042388

ABSTRACT:
This invention concerns compounds having the Z-configuration of formula: ##STR1## or salts thereof, wherein R represents an optionally substituted aryl or heteroaryl radical, R.sup.1, R.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxy, hydroxy (C.sub.1 -C.sub.6)alkyl, halogen, halo(C.sub.1 -C.sub.6)alkyl, carboxy(C.sub.1 -C.sub.6)alkyl, optionally substituted aryl or heteroaryl or optionally substituted aralkyl or heteroarylalkyl; n represents 0, 1 or 2; R.sup.4 and R.sup.5 each independently represent hydrogen or a substituent selected from lower alkyl, optionally substituted aryl and optionally substituted aralkyl or R.sup.4 and R.sup.5 are geminal C.sub.1 -C.sub.6 alkyl substituents and R.sup.6 is hydrogen or C.sub.1 -C.sub.6 alkyl which possess antiinflammatory activity.

REFERENCES:
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patent: 4837329 (1989-06-01), Crossley
patent: 5001131 (1991-03-01), Crossley
patent: 5112832 (1992-05-01), Crossley
Baum, Chem Ber, vol. 121, pp. 411-415, 1988.
Thummel, J Org Chem. vol. 49, pp. 2208-2212, 1984.
Dammertz, Arch Pharm, vol. 313, pp. 826-832, 1980.

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