Z-benzylidene-tetrahydroquinolines and analogues thereof

Details Z-benzylidene-tetrahydroquinolines and analogues thereof Z-benzylidene-tetrahydroquinolines and analogues thereof

1994-12-01

1997-01-28

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514307, 514256, 546176, 546148, 544242, C07D21512, A61K 3147

Patent

active

055978347

ABSTRACT:
This invention concerns compounds having the Z-configuration of formula: ##STR1## or salts thereof, wherein R represents an optionally substituted aryl or heteroaryl radical, R.sup.1, R.sup.2 and R.sup.3 each independently represent hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, (C.sub.1 -C.sub.6 alkoxy)carbonyl, carboxy, hydroxy (C.sub.1 -C.sub.6)alkyl, halogen, halo(C.sub.1 -C.sub.6)alkyl, carboxy(C.sub.1 -C.sub.6)alkyl, optionally substituted aryl or heteroaryl or optionally substituted aralkyl or heteroarylalkyl; n represents O, 1 or 2; R.sup.4 and R.sup.5 each independently represent hydrogen or a substituent selected from lower alkyl, optionally substituted aryl and optionally substituted aralkyl or R.sup.4 and R.sup.5 are geminal C.sub.1 -C.sub.6 alkyl substituents and R.sup.6 is hydrogen or C.sub.1 -C.sub.6 alkyl which possess antiinflammatory activity.

REFERENCES:
patent: 4837329 (1989-06-01), Crossley
Nikolaus Lodde, Arch. Pharm. (Weinheim), "Intramolekulare Aromatenalkylierungen . . . ", 312, pp. 940-950, 1979.
Dammertz and Reimann, Arch. Pharm. (Weinheim) 313, 826-832 (1980).

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