Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1984-05-09
1986-07-22
Milestone, Norma S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514473, 549214, 549295, 549273, C07D30758, C07F 708, A61K 31695, A61K 31365
Patent
active
046020063
ABSTRACT:
Compounds of the formula ##STR1## wherein n is 1-3; R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl or aryl lower alkyl wherein when aryl is phenyl it is unsubstituted or independently substituted with one or more halo, lower alkyl or lower alkoxy groups; and R.sup.4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, trialkylsilyl, aryl or aryl lower alkyl wherein when aryl is phenyl it is unsubstituted or independently substituted by one or more halo, lower alkyl or lower alkoxy groups; excluding those compounds wherein R.sup.1 and R.sup.2 are hydrogen and R.sup.4 is ethyl, propyl or butyl. These compounds are useful as protease inhibitors.
REFERENCES:
patent: 3770776 (1973-11-01), Collins et al.
Chemical Abstracts, 92:181374t (1980).
Chemical Abstracts, 95:198981y (1981).
Daniels et al., J. Biol. Chem., vol. 258, No. 24, pp. 15046-15053 (1983).
Bohlmann and Zdero, 102 Chem. Ber. 1034-1036 (1969).
Wat et al., vol. 9, No. 1, Biochemical Systematics and Ecology, pp. 59-62 (1981).
Bohlmann and Jakupovic, vol. 18, No. 8, Phytochemistry, pp. 1367-1370 (1979).
Sofia et al., 48 J. Org. Chem. 3318-3325 (1983).
Chakravarty et al., vol. 257, No. 2, Journal of Biological Chemistry, pp. 610-612 (1982).
Krafft et al., vol. 103, No. 18, J. Am. Chem. Soc., 5459-5466.
Krantz Alexander
Spencer Robin W.
Tam Tim F.
Milestone Norma S.
Moran Tom M.
Syntex (U.S.A.) Inc.
Toth Liza K.
LandOfFree
Ynenolactone protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ynenolactone protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ynenolactone protease inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-866156