Yersinia species compositions

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C530S350000

Reexamination Certificate

active

07344718

ABSTRACT:
A method of protecting an animal from infections with pathogens originating fromYersiniacomprising administering an isolated or recombinant YscF protein to the animal is disclosed. The isolated or recombinant YscF protein may be administered as a vaccine. An isolated or recombinant YscF protein capable of conferring protection to an animal against a pathogen of aYersiniaorigin is further disclosed. Nucleic acid molecules encoding the isolated or recombinant YscF protein are also disclosed. In other embodiments, antibodies generated against the isolated or recombinant YscF protein capable of conferring protection to an animal against a pathogen or aYersiniaorigin and uses of the antibodies are described.

REFERENCES:
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patent: 6261561 (2001-07-01), Stewart et al.
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patent: WO 02/077249 (2002-10-01), None
Plotkin et al (VACCINES W B Saunders Co. 1988, p. 571).
8th International Symposium on Yersinia, Sep. 4-8, 2002. Turku, Finland.
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Edqvist et al., YscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion System, Journal of Bacteriology, Apr. 2003, pp. 2259-2266, vol. 185, No. 7.
Hoiczyk et al., Polymerization of a single protein of the pathogen Yersinia entercolitica into needles punctures eukaryotic cells, PNAS, Apr. 10, 2001, pp. 4669-4674, vol. 98, No. 8.
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Wilson et al., Role of EscF, a putative needle complex protein, in the type III protein translocation system of enteropathogenicEscherichia coli, Cellular Microbiology, 2001, pp. 753-762, vol. 3, No. 11.
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Supplementary Partial European Search Report, EP 04 74 9309, dated Mar. 29, 2007.

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