Yersinia INV nucleic acids

Details Yersinia INV nucleic acids Yersinia INV nucleic acids

1992-05-22

1994-08-16

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 691, 4352523, 43525233, 4353201, 536 2432, C12N 1531, C12N 121, C12Q 168

Patent

active

053388429

ABSTRACT:
Novel methods and microorganisms are provided, where novel genetic mammalian cell invasive capability is imparted to a microorganism by the introduction of an exogenous inv gene. The resulting organisms are then capable of binding to mammalian cells and are transferred to the cytoplasm. Other novel genetic capabilities may be imparted to the unicellular microorganism, which may serve as a vaccine for one or more pathogens or may introduce genetic capabilities or foreign molecules into a mammalian host cell. The sequences may be used for an in vitro screen for pathogenicity.

REFERENCES:
Small, P. L. C. et al. 1988 Infection and Immunity, vol. 56, pp. 225-229.
Falkow, S. 1991, Cell vol. 65, pp. 1099-1102.
Miller, V. 1992, ASM News vol. 58, pp. 26-33.
Isberg, R. R. et al. 1985, Nature, vol. 317, pp. 262-264.
Infection and Immunity, vol. 56, 5, (May 1988), Miller et al. "Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells", 1242-1248.
Biological Abstracts, vol. 86, 2. (Jul. 15, 1988) Van Der Walt, "A comparative study of the growth of campylobacter fetus strains in liquid media", Abstract 15466.
Infection and immunity, vol. 57, 1, (Jan. 1989), Miller et al. "The ail locus is found uniquely in Yershinia enterocolitica serotypes commonly associated with disease", 121-131.
Journal of clinical Microbiology, vol. 26, 2, (Feb., 1988) Venkatesan et al. "Development and testing of invasion-associated DNA probes for detection of Shigella spp. and enteroinvasive Escherichia coli," 261-266.
Canadian Journal of Microbiology, vol. 21, 12, (Dec. 1975) "Ingestion and Survival of Y. pseudotuberculosis in HeLa cells", 1997-2007.
Cell, vol. 50 (Aug., 1987) 769-778, "Identification of Invasin: A Protein that allows enteric bacteria to Penetrate Cultured Mammalian Cells", Ralph R. Isberg et al.
Isbers et al, Proceedings of the National Academy of Sciences USA, 85(18): 6682-6686, (Sep. 1988) Title: Cultured mamalian cells attach to the invasin protein of Yersinia pseudotubclosis.
Formal et al., Infection and Immunity. 46(2): 465-469 (Nov. 1984). Title: Oral vaccination of monkeys with an invasive Escherichia coli K12 hybrid expression Shigella flexneri 2a somatic antigen.

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