Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1985-11-26
1990-01-23
Teskin, Robin
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435255, 435256, 435320, 935 28, 935 37, 935 56, 935 65, 935 69, 536 27, C12P 2100, C12P 2102, C12N 1500, C12N 500
Patent
active
048958000
ABSTRACT:
Novel DNA constructs comprising regulatory regions plus the structural coding region for hepatitis B surface antigen (HBsAg) are disclosed. The regulatory regions employed are responsive to methanol, non-catabolite repressing carbon sources and catabolite repressing carbon sources followed by carbon source starvation. The novel constructs are incorporated into a variety of linear and circular plasmids. Such plasmids are used to transform suitable hosts and ultimately used for the production and isolation of hepatitis B surface antigen in high yields.
REFERENCES:
patent: 4320194 (1982-03-01), Bull
patent: 4428941 (1984-01-01), Galibert et al.
patent: 4510245 (1985-04-01), Cousens et al.
patent: 4515714 (1985-05-01), Kawahara
patent: 4769238 (1988-09-01), Rutter et al.
patent: 4803164 (1989-02-01), Hitzman et al.
Miyanohara et al., Proc. Natl. Acad. Sci., vol. 80, pp. 1-5, "Expression of hepatitis B surface antigen gene in yeast".
Hitzeman et al., Nucl. Acids Res., vol. 11, pp. 2745-2763, "Expression of hepatitis B virus surface antigen in yeast".
Couderc et al., Biol. Abst., vol. 71, No. 62361, 1980, "Oxidation of methanol by the yeast Pichia postoris strain IF P-206 purification and properties of the alcohol oxidase".
Scherer et al., Proc. Natl. Acad. Sci., vol. 76(10), Oct. 1979, pp. 4951-4955, "Replacement of chromosome segments with altered DNA sequences constructed in vitro".
Roggenkamp et al., Mol. Gen. Conf. vol. 174, pp. 489-493, May 2, 1984, "Biosynthesis and regulation of the pentisonal methanol oxidase from the methylotropic yeast Hansenula polymorph".
Ledoboer et al., Nucl. Acids Res., vol. 13(9) May 10, 1985, pp. 3063-3082, "Molecular cloning and characterization of a gene coding for methanol oxidase from Hansenula polymorph".
Janowicz et al., Nucl. Acids Res., vol. 139(9) May 10, 1985, pp. 3043-3062, "Cloning and characterization of the DHAS gene encoding the major methanol assimilating enzyme".
Nature, P. Valenzuela et al, vol. 280, pp. 815-819 (8/30/79).
Proc. Natl. Acad. Sci. U.S.A., P. MacKay et al, vol. 78 (7), pp. 4510-4514 (7/81).
DNA, C. Liu et al, vol. 1 (3), pp. 213-221 (1982).
Nature, P. Valenzuela et al, vol. 298, pp. 347-350 (9/82).
Nucleic Acids Research, Y. Ono et al, vol. 11 (6), pp. 1747-1757 (1983).
Proc. Natl. Acad. Sci. U.S.A., D. Wampler et al, vol. 82, pp. 6830-6834 (10/85).
Buckholz Richard G.
Cregg James M.
Harpold Michael M.
Tschopp Juerg F.
Phillips J. E.
Phillips Petroleum Company
Teskin Robin
Woodrow Hal Brent
LandOfFree
Yeast production of hepatitis B surface antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Yeast production of hepatitis B surface antigen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Yeast production of hepatitis B surface antigen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-645121