Yeast expression vector and a method of making a recombinant...

Details Yeast expression vector and a method of making a recombinant... Yeast expression vector and a method of making a recombinant...

2001-12-20

2008-11-04

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S254200, C435S483000, C435S320100, C536S023100, C530S350000

Reexamination Certificate

active

07445775

ABSTRACT:
Vectors for the expression in yeast of mammalian plasminogen derivatives such as microplasminogen and miniplasminogen are presented. Methods for expression of these proteins in a methylotrophic yeast expression system are disclosed as well as the activation and stabilisation of the recombinant proteins. The proteins of this invention are used In the treatment of focal cerebral ischemic infarction and other thrombotic diseases.

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