Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1988-04-08
1991-12-31
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 691, 435 711, 4351721, 4351723, 4352402, 4352523, 435254, 435255, 4353201, 435224, 536 27, C12N 960, C12N 1500, C12N 116, C12P 2102
Patent
active
050772040
ABSTRACT:
Methods and compositions are provided for endopeptidase production, enhanced efficiencies of processing in vivo and in vitro to provide for process polypeptides, and purified enzyme for in vitro processing of polypeptides. The endopeptidase is specific for dibasic amino acid sites, cleaving at the C-side of the dipeptide.
The S. cerevisiae strain pYBCA-5 (truncated KEX2) was deposited at the A.T.C.C. on June 21, 1984 and given Accession No. 20717.
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Julius et al., (1984) Cell 36:309-318.
Mortimer et al., in Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression (Strathern, J. N., and Broach, J. R., Eds.) pp. 639-650 (1982).
Achstetter et al., (1981) Arch. Biochem. Biophys. 207:445-454.
Blair Lindley C.
Brake Anthony J.
Julius David
Thorner Jeremy W.
Chiron Corporation
Lebovitz Richard M.
Schwartz Richard A.
The Regents of the University of California
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