Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-05
1998-08-04
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
43525411, 4352542, 43525421, G01N 3353
Patent
active
057891842
ABSTRACT:
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of .alpha.-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
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Broach Jim
Fowlkes Dana M.
Klein Christine
Manfredi John
Murphy Andrew J.
Cadus Pharmaceutical Corporation
DeConti, Jr. Giulio A.
Kara Catherine J.
Ketter James
Yucel Irem
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