Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
1999-03-18
2001-10-02
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S320100, C435S252300, C435S325000, C530S350000
Reexamination Certificate
active
06297036
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be agonists, antagonists and/or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides.
BACKGROUND OF THE INVENTION
The drug discovery process is currently undergoing a fundamental revolution as it embraces ‘functional genomics’, that is, high throughput genome- or gene-based biology. This approach is rapidly superceding earlier approaches based on ‘positional cloning’. A phenotype, that is a biological function or genetic disease, would be identified and this would then be tracked back to the responsible gene, based on its genetic map position.
Functional genomics relies heavily on the various tools of bioinformatics to identify gene sequences of potential interest from the many molecular biology databases now available. There is a continuing need to identify and characterise further genes and their related polypeptides/proteins, as targets for drug discovery.
SUMMARY OF THE INVENTION
The present invention relates to HTLAR33, in particular HTLAR33 polypeptides and HTLAR33 polynucleotides, recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, hereinafter referred to as “the Diseases”, amongst others. In a further aspect, the invention relates to methods for identifying agonists and antagonists/inhibitors using the materials provided by the invention, and treating conditions associated with HTLAR33 imbalance with the identified compounds. In a still further aspect, the invention relates to diagnostic assays for detecting diseases associated with inappropriate HTLAR33 activity or levels.
REFERENCES:
Garrett et al. “TheSaccharomyces cerevisiaeYAK1 Gene Encodes a Protein Kinase that Is Induced by Early in the Cell Cycle”, Molecular and Cellular Biology, vol. 11 (8), pp. 4045-4052 (1991).
Tugendreich et al. “Linking yeast genetics to mammalian genomes: Identification and mapping of the Homolog of CDC27 via the expressed sequence tag (EST) data base”, Proc. Natl. Acad. Sci. USA, vol. pp. 10031-10035 (1993).
Song et al. Isolation of Human and Murine Homologues of the Drosophila Minibrain Gene: Human Homologue Maps to 21q22.2 in the Down Syndrome “Critical Region”, Genomics, vol. 38, pp. 331-339 (1996).
Copy of Partial EP Search Report.
Kentrup et al. “Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII”, J. Biol. Chem., vol. 271 (7), pp. 3488-3495 (1996).
Tejedor et al. “Minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila”, Neuron, vol. 14 (2), pp. 287-301 (1995).
Bergsma Derk
Shabon Usman
Han William T.
King William T.
Monshipouri Maryam
Prouty Rebecca E.
Ratner & Prestia
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