Y-carboxyglutamate derivative, method for preparing the same and

Details Y-carboxyglutamate derivative, method for preparing the same and Y-carboxyglutamate derivative, method for preparing the same and

1990-08-31

1992-11-17

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530334, 530336, C07K 106, C07K 104, C07K 304, C07K 710

Patent

active

051644835

ABSTRACT:
Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts thereof are prepared by introducing .gamma.-carboxyglutamic acid into the amino acid sequence of said osteocalcin by employing a protective L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof in the appropriate position in the reacting sequence of amino acids which form the osteocalcin.

REFERENCES:
patent: 4212795 (1980-07-01), Hughes et al.
patent: 4410506 (1983-10-01), Price et al.
patent: 4438208 (1984-03-01), Deftos et al.
Poser et al., J. Biol. Chem. 255:8685-8691, Sep. 25, 1981.
Marki et al., Helvetica Chimica Acta 60:807-815, 1977.
Zee-Cheng et al., Bioc. and Biophys. Res. Comm. 94:1128-1132, Jun. 30, 1980.
Danishefsky et al., J. Am. Chem. Soc., 101:4385-4386, Jul. 18, 1979.
Barany et al. "Solid-Phase Peptide Synthesis", pp. 1-255, in The Peptides, Gross et al., editors, 1980.
Biological Abstracts, vol. 87, 1989, abstract No. 122392, L. Simionescu et al., "Methods of Isolation and Purification of Bovine and Rat Osteocalcin".
Chemical Abstracts, vol. 112, No. 15, Apr. 9, 1990, p. 794, abstract No. 139828a.

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