Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2007-06-29
2010-10-26
Lilling, Herbert J. (Department: 1657)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S158000, C435S254220
Reexamination Certificate
active
07820414
ABSTRACT:
Disclosed herein are Xylitol dehydrogenase-inactivated and arabinose reductase-inhibited mutant ofCandida tropicalis, a method of producing a high yield of xylitol using the same, and xylitol produced by the method. More specifically, disclosed are a method for producing a high yield of xylitol, in which a high concentration of xylose contained in a biomass hydrolyzate is converted to xylitol using xylitol dehydrogenase-inactivated mutant ofCandida tropicalis, without controlling dissolved oxygen to a low level, as well as xylitol produced according to the method. Also disclosed are a xylitol production method, in which the production of byproduct arabitol, which is produced when using a biomass as a substrate and adversely affects the yield of xylitol, is significantly reduced through the use ofCandida tropicalismutant ara-89 (KCTC 11136bp) having an inhibited activity of arabinose reductase converting arabinose to arabitol, thus increasing xylitol productivity, as well as xylitol produced by the method.
REFERENCES:
patent: 7226761 (2007-06-01), Miasnikov et al.
Ko, Byoung Sam, et al., “Enhancement of xylitol productivity and yield using a xylitol dehydrogenase gene-disrupted mutant ofCandida tropicalisunder fully aerobic conditions,”Biotechnol Lett, 2006, vol. 28, pp. 1159-1162.
Ko, Byoung Sam, et al., “Production of xylitol from D-xylose by a xylitol dehydrogenase gene-disrupted mutant ofCandida tropicalis,” Applied and Environmental Microbiology, Jun. 2006, pp. 4207-4213.
Kim Jung Hoe
Ko Byoung Sam
Korea Advanced Institute of Science and Technology
Lilling Herbert J.
LPBIO Co., Ltd.
Rothwell Figg Ernst & Manbeck P.C.
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