Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1984-03-23
1987-10-13
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514822, 514825, 514886, 514802, 514824, 536118, 536 182, 536 41, 536124, 536 185, 536 21, C07H 1100, C07H 1312, A61K 3172, A61K 31095
Patent
active
046999000
ABSTRACT:
This invention relates to new xylane sulfates having an apparent molar weight comprised between 7000 and 12000.
This invention relates also to a process for their preparation by fractionation, and to the therapeutic application thereof as anti-thrombosis and hypolipemic agents.
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patent: 4221907 (1980-09-01), Nair et al.
patent: 4281108 (1981-07-01), Fussi
patent: 4301153 (1981-11-01), Rosenberg
Soria et al., Anticoagulant Activities of a Pentesane Polysulphate: Comparison With Standard Meparin and a Fraction of Low Molecules Weight Heparin, Thrombosis Research 19, 455-63, (1980).
Esquivel et al., Comparison Between Commercial Heparin, Low Molecular Weight Heparin and Pentesan Polysulfate on Memostasis and Platelets in Vivo, Thrombosis Research 28, 389-99, (1982).
Vinazzer et al., Influence on the Clotting System Mechanism of Sodium Pentesan Polysulfate (SP54) in Comparison to Commercial Beef Lung Sodium Heparin, Thrombosis Research 20, 57-68, (1980).
Vinazzer et al., Influence of Heparin of Different Heparin Fractions and of a Low Molecular Weight Heparin Like Substance on the Mechanism of Fibrinolysis, Thrombosis Research 27, 341-52, (1982).
Evans et al., Reaction of Carbohydrates with Methylsulfonyl Chloride in N,N-Dimethylformamide Preparation of Some Methyl 6-chloro-6-deoxyglycosides, Chem Abs 68,87497t, (1968).
Hirano et al., Some N-Acyl Derivatives of N-Desulphated Heparin, Carbohydrate Research 59, pp. 285-288, (1977).
Bayol Alain
Lansen Jacqueline
Maffrand Jean P.
Pereillo Jean-Marie
Vallee Eric
Griffin Ronald W.
Sanofi (S.A.)
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