Xeroderma pigmentosum-deficient mouse

Details Xeroderma pigmentosum-deficient mouse Xeroderma pigmentosum-deficient mouse

1996-09-06

1999-09-07

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

800 9, 800 18, 424 91, 424 92, 4353251, 435354, 435 721, 435455, 435 29, C12N 500, C12N 506, G01N 33567, A61K 4900

Patent

active

059489529

ABSTRACT:
An Xeroderma pigmentosum-deficient mouse, as well as methods for screening for the damaging and tumorigenic effect of ultraviolet light or a chemical DNA damaging agent, are disclosed.

REFERENCES:
Sands et al, Nature, 377:162-165 (1995).
Cheo et al, J. Cell. Biochem., Abstract Supplement 21A:309, Abstract No. C5-328, 24th Annual Keystone (1995).
Li et al, Nature Genetics, 5:413-147 (1993).
Legerski et al, Nature, 359:70-73 (1992).
Cleaver, Cell, 76:1-4 (1994).
Cleaver et al, The Metabolic Basis of Inherited Disease, pp. 4393-4419 (McGraw-Hill, New York (1995)).
Cheo et al. Characterization of defective nucleotide excision repair in XPC mutant mice. Mutation Research, vol. 374, pp. 1-9, 1997.
Fassler et al. Knockout Mice: How to Make them and Why. Int. Arch. Allergy Immunol., vol. 106, pp. 323-334, 1995.

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