Chemistry: molecular biology and microbiology – Vector – per se
Patent
1994-03-15
1998-10-13
Ketter, James
Chemistry: molecular biology and microbiology
Vector, per se
435325, 536 232, C12N 1563, C12N 510, C12N 1554
Patent
active
058211179
ABSTRACT:
DNA sequences encoding a porcine Gal.alpha.(1,3) galactosyl transferase and clones containing such sequences are provided. The porcine Gal.alpha.(1,3) galactosyl transferase produces the Gal.alpha.(1,3)Gal epitope on the surfaces of porcine cells. This epitope is recognized by human anti-Gal.alpha.(1,3)Gal antibodies which are responsible for hyperacute rejection of xenotransplanted pig cells, tissues and organs.
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McKenzie Ian F. C.
Sandrin Mauro S.
Brusca John S.
Fidel Seth A.
Ketter James
Klee Maurice M.
The Austin Research Institute
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