Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Intentional mixture of two or more micro-organisms – cells,...
Patent
1994-05-16
1997-08-19
Ziska, Suzanne E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Intentional mixture of two or more micro-organisms, cells,...
424 937, 424580, A01N 6300, A61K 3526
Patent
active
056585640
ABSTRACT:
The invention features methods of replacing thymus function and inducing immunological tolerance.
REFERENCES:
patent: 4772552 (1988-09-01), Hercend et al.
patent: 5087570 (1992-02-01), Weissman et al.
patent: 5160490 (1992-11-01), Naughton et al.
08/150739 Nov. 10, 1993.
08/129608 Sep. 29, 1993.
08/126122 Sep. 23, 1993.
08/114072 Aug. 30, 1993.
Aksentijeivch, I., et al., "Natural Antibodies Can Inhibit Bone Marrow Engraftment In the Rat.fwdarw.Mouse Species Combination", J. Immunology 147:4140-4146 (1991).
Anklesaria, P., et al., "Engraftment Of A Clonal Bone Marrow Stromal Cell Line In Vivo Stimulates Hematopoietic Recovery From Total Body Irradiation", Proc. Natl. Acad. Sci. USA 84:7681-7685 (1987).
Auchincloss, Federal Research in Progress, I.D. No.: 5RO1HL36372-05.
Ba, D., et al., "Restoration Of T Cell Depression And Suppression Of Blood Pressure In Spontaneously Hypertensive Rats (SHR) By Thymus Grafts or Thymus Extracts", J. Immunology 128:1211-1216 (1982).
Ba, D., et al. "Restoration Of Immune Functions And Subsequent Suppression Of Blood Pressure In Spontaneously Hypertensive Rats By Allogeneic, Xenogeneic Thymus Grafts Or Injection Of Thymus Extracts", Chinese Med. J. 94(6):369-374 (1981).
Barber, W. Henry, et al., "Long-Term Results Of A Controlled Prospective Study With Transfusion Of Donor-Specific Bone Marrow In 57 Cadaveric Renal Allograft Recipients", Transplantation 51:070-075 (Jan., 1991).
Belo, et al., Int. Immunol., 1:105, 1989.
Billingham, R.E., et al., "Actively Acquired Tolerance Of Foreign Cells", Nature 172:603-606 (Jul. 4, 1953 to Dec. 26, 1953).
Bix, M., et al., "Inefficient Positive Selection Of T Cells Directed By Haematopoietic Cells", Nature 359:330-333 (1992).
Buckley, R.H., et al., "Correction Of Severe Combined Immunodeficiency By Fetal Liver Cells", N.E. J. Med. 194:1076-1081 (1976).
Campos, L., et al., "Prolonged Survival Of Rat Orthotopic Liver Allografts After Intrathymic Inoculation Of Donor-Strain Cells", Transplantation 54(4):866-869 (1993).
Cosimi, A. B., et al., "Experience With Large-Dose Intravenous Antithymocyte Globulin In Primates And Man", Surgery 68(1):54-61 (1970).
Cooper, D.K.C., et al., "Effects of Cyclosporine And Antibody Adsorption On Pig Cardiac Xenograft Survival In The Baboon", J. Heart Transplant. 7(3):238-246 (1988).
Dalmassio, Federal Research in Progress, I.D. No.: 0003; 73094; 618 "Inhibition of complement activation in xenotransplantation".
Deugnier, M., et al., "Rat bone marrow cells undergo thymopoiesis in mouse fetal thymic organ culture", Eur. J. Immunol. 20:2075-2081 (1990).
El-Ezz, A.Y., et al., "T-Cell Development In Thymectomized Fully Xenogeneic Chimeras (Rat.fwdarw.Mouse): Evidence For Extrathymic T-Cell Maturation", FASB J 6(5):A1697 (1992).
El Ezz, A.Y., et al., "Mixed Xenogeneic Chimeras (Mouse+Rat.fwdarw.Mouse): The Mouse Thymus Is Sufficient To Support Xenogeneic Rat T-Cell Maturation", J. Cell. Biochem. Supp. O. (16 part A):181 (1992).
Fiedler, et al., "Experimental xenografting in widely divergent species, modification of the hyperacute xenogeneic rejection of kidneys from pigs (donor) by extreme hemodilution of dogs" 163:137-153, 1974.
Fischel R.J., et al., "Prolonged Survival of a Discordant Cardiac Xenograft in a Rhesus Monkey", Transplantation Proc. 23(1):589-590 (1991).
Fischel, R.J., et al., "Removal of IgM Anti-Endothelial Antibodies Results in Prolonged Cardiac Xenograft Survival", Transplantation Proc. 23(3):1077-1078 (1990).
Gao, E., et al., "Strong T Cell Tolerance In Parent.fwdarw.F.sub.1 Bone Marrow Chimeras Prepared With Supralethal Irradiation", J. Exp. Med. 171:1101-1121 (1990).
Guillemot, F.P., et al., "Cells Expressing la Antigens In The Avian Thymus", J. Exp. Med. 160:1803-1819 (1984).
Gustafsson, K., et al., "Structure of miniature swine class II DRB genes: Conservation of hypervariable amino acid residues between distantly related mammalian species", Proc. Natl. Acad. Soc. USA 87:9798-9802 (1990).
Guzzetta, P., et al., "Induction Of Kidney Transplantation Tolerance Across Major Histocompatibility Complex Barriers By Bone Marrow Transplantation In Miniature Swine", Transplantation 51(4):862-866 (1991).
Hallenbeck, G.A., et al., "Restoration of Immunologic Competence of Neonatally Thymectomized Mice by Isogeneic and Xenogeneic Thymic Grafts", Proc. Soc. Exp. Biol. Med. 130(4):1142-1146 (1969).
Hougen, H.P., et al., "The thymus reconstituted nude rat: Lymphocyte subpopulations and immunological characteristics", Thymus 10:207-217 (1987).
Hammer, C., et al., "Preformed Natural Antibodies in Animals and Man", Europ. Surg. Res. 5:162-166 (1973).
Hougen, H.P., et al., "Effects of xenogeneic, allogeneic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat", Laboratory Animals 21:103-111 (1987).
Iidstad, S.T., et al., "Cross-species Bone Marrow Transplantation: Evidence for Tolerance Induction, Stem Cell Engraftment, and Maturation of T Lymphocytes in a Xenogeneic Stromal Environment (Rat.fwdarw.Mouse)", J. Exp. Med. 174:467-478 (1991).
Iidstad, S.T., et al., "Reconstitution with xyngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts", Nature 307:168-170 (1984).
Irwin, M.J., et al., "Species-Restricted Interactions Between CD8 And the .alpha.3 Domain Of Class I Influence The Magnitude Of The Xenogeneic Response", J. Exp. Med. 170:1091-1101 (1989).
Jotereau, F.V., et al., "Demonstration Of A Cyclic Renewal Of The Lymphocyte Precursor Cells In The Quail Thymus During Embryonic And Perinatal Life", J. Immunol. 129(5):1869-1877 (1982).
Jotereau, F.V., et al., "Lymphoid stem cell homing to the early thymic primordium of the avian embryo", Euro. J. Immunol. 10:620-627 (1980).
Kollmann, T.R., et al., "The Concurrent Maturation of Mouse and Human Thymocytes in Human Fetal Thymus Implanted in NlH-beige-nude-xid Mice is Associated with the Reconstitution of the Murine Immune System", J. Exp. Med. 177:821-832 (1993).
Kosaka, H., et al., "Tolerance of CD8+ T Cells Developing in Parent.fwdarw.F.sub.1 Chimeras Prepared with Supralethal Irradiation: Step-Wise Induction of Tolerance in the Intrathymic and Extrathymic Environments", J. Exp. Med. 177:367-378 (1993).
Krowka, J.F., et al., "Human T Cells In The SCID-hu Mouse Are Phenotypically Normal And Functionally Competent", J. Immunol. 146(11):3751-3756 (1991).
Latinne, D., et al., "Xenotransplantation From Pig to Cynomolgus Monkey: Approach Toward Tolerant Induction", Transplantation Proc. 25(1):336-338 (1993).
Lawrance, S.K., et al., "Transgenic HLA-DR.alpha. Faithfully Reconstitutes IE-Controlled Immune Functions and Induces Cross-Tolerance to E.alpha. in E.alpha..sup.0 Mutant Mice", Cell 56:583-594 (1989).
Le Douarin, N.M., et al., "Ontogeny of Primary Lymphoid Organs and Lymphoid Stem Cells", Am. J. Anat. 170:261-299 (1984).
Le Douarin, N.M., et al., "Distribution and Origin of la-Positive Cells in the Avian Thymus Analyzed by Means of Monoclonal Antibodies in Heterospecific Chimeras", Prog. Immunol. V. pp. 613-631 (1983).
Le Douarin, N.M., et al., "Demonstration Of A Cyclic Renewal Of The Lymphocyte Precursor Cells In the Quail Thymus During Embryonic And Perinatal Life" J. Immunol. 129:1869 (1982).
Le Douarin, N.M., et al., "Tracing Of Cells Of The Avian Thymus Through Embryonic Life In Interspecific Chimeras", J. Exp. Med. 142:17-40 (1975).
Lee, L.A., "Murine T Cell Maturation In Discordant Xenogeneic Fetal Thymus Grafts", J. Immunol. 150(8 part 2):321A (1993).
Lubin, I., et al., "Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation", Science 252:427-431 (1991).
Lucas, P.J., et al., "The Human Antimurine Xenogeneic Cytotoxic Response", J. Immunol. 144(12):4548-4554 (1990).
Manning, J.K., et al., "Transplantation of Cultured Thymic Fragments: Results in Nude Mice", Scand. J. Immunol. 19:403-410 (1984).
Manning, J.K., et al., "Effect Of Transplantation Of Xenogeneic Cultured Thymic Fragments (CTF) in Nude Mice," Federation Proceedings 41(3):605 (1982).
Markmann, J.F., et al., "Deletion Of Donor-Reactive
Sachs David H.
Sykes Megan
Myers Louis
The General Hospital Corporation
Ziska Suzanne E.
LandOfFree
Xenograft thymus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Xenograft thymus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Xenograft thymus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1102740