Xenogeneic tissue implant in ear pinna

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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800DIG3, 800DIG4, 800DIG5, 4352402, 424 937, 424578, A01K 6700, A61K 4900

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active

055169775

ABSTRACT:
Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the ear pinna and closing the incision. The tissue is found to be rapidly vascularized and can be productively infected with HIV.

REFERENCES:
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Mukamel et al., "A Mouse Ear Reaction for Assessment of Human Lymphocyte Immunocompetence," Immunobiol. (1985) 169: 21-29.
Meyvisch & Mareel, "Site Induced Differences in Spontaneous Metastasis of MO4 Mouse Fibrosarcoma Cells," Invasion Metastasis. (1985) 5: 185-192.
Fulmer et al., "Transplantation of Cardiac Tissue into the Mouse Ear," American Journal of Anatomy (1963) 113: 273-281.
Namikawa et al., "Long Term Human Hematopoiesis in the SCID-hu Mouse," J. Exp. Med. (1990) 172: 1055-1063.
McCune, "HIV-1: The Infective Process In Vivo" Cell (1991) 64: 351-363.
Mombaerts et al., "RAG-1-Deficient Mice Have no Mature B and T Lymphocytes" Cell (1992) 68: 869-877.
McCune et al., "The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function," Science (1988) 241: 1632-1639.

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