Xenogeneic lymph node in mammary fat pad

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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424578, 424580, 424582, 424553, 424 937, 800DIG5, A61K 3500

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active

054343410

ABSTRACT:
Methods and chimeric immunocompromised hosts comprising functional xenogeneic organs are provided, particularly hematopoietic organs, where the xenogeneic organ is engrafted into a mammary fat pad. Exemplary is the engrafting of lymph node with mesenteric tissue comprising small portions of blood vessels transplanted into mammary fat pad of a scid/scid mouse. The engraftment in the mammary fat pad provides for efficiencies in transplantation, higher success rate of transplantation, and improved growth of the transplanted organ.

REFERENCES:
Bosma et al., Nature 301: 527-530 (1983).
McCune et al., Science 241: 1632-1639 (1988).
Dubois et al., Differentiation 35: 72-82 (1987).
Sheffield et al., J. Dairy Sci. 69: 1141-1147 (1986).

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