Xanthylium dyes that are well retained in mitochondria

Details Xanthylium dyes that are well retained in mitochondria Xanthylium dyes that are well retained in mitochondria

1993-10-25

1995-10-17

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548417, 549227, C07D31188, C07D22122

Patent

active

054592682

ABSTRACT:
The dyes of the present invention are fluorescent substituted 3',6'-diaminoxanthenes and their reduced analogs 3',6'-diaminodihydroxanthenes, which are oxidized to the fluorescent form of the dye in situ. In their oxidized form, the dyes selectively localize within mitochondria. The dyes of the present invention include an alkylating group that is covalently attached that allows their retention in mitochondria even after cell death, fixation, and permeabilization.

REFERENCES:
Haugland, et al., Molecular Probes Handbook of Fluorescent Probes and Research Chemicals, Set 30 (1992).
Rothe, et al., Journal of Immunological Methods, 138, 133 (1991).
Martinez, et al., EXP Cell Res., 164, 551 (1986).
Kliot-Fields, et al., Somatic Cell Genetics, 9, 375 (1983).
Riedy, et al., Cytometry, 12, 133 (1991).
Haugland, Molecular Probes Handbook of Fluorescent Probes and Research Chemicals, Set 24 (1992).

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