Xanthone derivatives and process for producing the same

Details Xanthone derivatives and process for producing the same Xanthone derivatives and process for producing the same

1986-12-02

1989-03-28

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549392, 514869, A61K 3135, C07D31186

Patent

active

048164798

ABSTRACT:
Xanthone derivatives of the formula (I): ##STR1## wherein W, X, Y and Z which may be the same or different represent a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; A is a hydrogen atom B is a hydroxymethyl group, a lower alkoxycarbonyl group having 1 to 4 carbon atoms, or a carboxyl group, provided that a --O--CH.sub.2 --B group is bonded to the 2- or 3-position of the xanthone ring and that there is no case in which X, Y, and Z are each a hydrogen atom concurrently; as well as intoxic salts thereof when B is a carboxyl group, and a process for preparing the same are disclosed.
The compounds of formula (I) in accordance with the present invention are useful as diuretics having uricosuric activity and can be used in the treatment of edema or hypertension.

REFERENCES:
patent: 3758506 (1973-09-01), Godfroid et al.
Coffey, Rodd's Chemistry of Carbon Compounds, 2nd ed., vol. IV, pp. 316-335 (1977).
Mainkur. Chem. Abs. 59, 9994a-c (1963).
Chemical Abstracts, vol. 72, No. 11, Mar. 16, 1970, p. 396, column 1, Abstract No. 55161v, Columbus, Ohio, U.S.; Puranik et al: "Furano Compounds IV", & INdian J. of Appl. Chem. 1968, 31(3-4), 105-107.
Chemical Abstracts, vol. 57, No. 10, Nov. 12, 1962, columns 11979a-11980a, Columbus, Ohio, U.S.; F. Scheinmann "Xanthone series V. Infrared spectra of substituted and extended xanthones", & Tetrahedron, 1962, 18, 853-858.
Shutske et al., "[(3-Aryl-1,2-benzisoxazol-6-61)oxy]acetic Acids. A new Diuretic Series", J. Med. Chem., 1982, 25, pp. 36-44.
Platner et al., "Substituted 5,6-Dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic Acids; High-Ceiling Diuretics with Uricosuric Activity", J. Med. Chem., 1984, 27, pp. 1016-1026.

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