Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2007-06-20
2010-06-15
Meller, Michael V (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Reexamination Certificate
active
07736677
ABSTRACT:
Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
REFERENCES:
patent: 6391346 (2002-05-01), Newmark et al.
patent: 6689398 (2004-02-01), Haridas et al.
patent: 2003/0035851 (2003-02-01), Chen
patent: 2003/0180402 (2003-09-01), Jia et al.
patent: 2004/0086580 (2004-05-01), Tripp et al.
patent: 2004/0115290 (2004-06-01), Tripp et al.
patent: 2004/0151792 (2004-08-01), Tripp et al.
patent: 2005/0020630 (2005-01-01), Connolly et al.
patent: 2005/0058722 (2005-03-01), Managoli
patent: 2007/0042063 (2007-02-01), Tripp et al.
patent: 2007/0154576 (2007-07-01), Tripp et al.
patent: 2008/0026088 (2008-01-01), Tripp et al.
patent: 2008/0031894 (2008-02-01), Tripp et al.
patent: 2008/0031982 (2008-02-01), Tripp et al.
patent: 2008/0031986 (2008-02-01), Tripp et al.
patent: 2008/0033057 (2008-02-01), Tripp et al.
patent: 2008/0051465 (2008-02-01), Tripp et al.
patent: 19939350 (1999-08-01), None
patent: 9818745 (1998-05-01), None
patent: WO 01/03687 (2001-01-01), None
Arner, P. Insulin resistance in type 2 diabetes—role of the adipokines. Curr Mol Med.;5(3):333-9, (May 2005).
Berenbaum, M. C. What is synergy? Pharmacol Rev 41(2), 93-141, (1989).
Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46(1): 3-10, (1997).
Cho et al., J Biol Chem 276:38345-38352 (2001).
Cho et al., Science 292:1728-1731 (2001).
Chou, T.C. and P. Talalay. Quantitative analysis of dose-effect relationships; the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55, (1984).
Choy EHS and Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Eng J Med. 344:907-916, 2001.
Crowley, M. T., et al,. J. Exp. Med. 186: 1027-1039, (1997).
Dignam, et al., Nucl Acids Res 11:1475-1489, (1983).
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., and Paschke, R. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun, 290: 1084-1089, (2002).
Hibi, M., Nakajima, K., Hirano T. IL-6 cytokine family and signal transduction: a model of the cytokine system. J Mol Med. 74(1):1-12, (Jan. 1996).
Hofstee, B.H. Non-inverted versus inverted plots in enzyme kinetics. Nature 184:1296-1298, (1959).
Hutchcroft, J. E., Harrison, M. L. & Geahlen, R. L. (1992). Association of the 72-kDa protein-tyrosine kinase Ptk72 with the B-cell antigen receptor. J. Biol. Chem. 267: 8613-8619, (1992).
Jiang, K., et al., Blood 101, 236-244, (2003).
Kasturi, R. and Joshi, V. C. Hormonal regulation of stearoyl coenzyme A desaturase activity and lipogenesis during adipose conversion of 3T3-L1 cells. J Biol Chem, 257: 12224-12230, (1982).
Kostich, M., et al., Human Members of the Eukaryotic Protein Kinase Family,Genome Biology3(9):research0043.1-0043.12, 2002.
Li, Y. and Lazar, M. A. Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2. Mol Endocrinol, 16: 1040-1048, (2002).
Martin, G., K. Schoonjans, et al. PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes. Atherosclerosis 137 Suppl: S75-80, (1998).
Moon KD, et al., Molecular Basis for a Direct Interaction between the Syk Protein-tyrosine Kinase and Phosphoinositide 3-Kinase. J. Biol. Chem. 280, No. 2, Issue of Jan. 14, pp. 1543-1551, (2005).
Oakes, N. D., P. G. Thalen, et al. Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Diabetes 50(5): 1158-65, (2001).
Parker, P. J., Caudwell, F. B., and Cohen, P. (1983)Eur. J. Biochem. 130:227-234.
Raeder, E. M., et al., J. Immunol. 163, 6785-6793, (1999).
Raz, I., Eldor, R., Cernea, S., and Shafrir, E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res Rev, 21: 3-14, (2005).
Stolovich et al. Mol Cell Biol Dec, 8101-8113 (2002).
Stumvoll, M. and H. U. Haring Glitazones: clinical effects and molecular mechanisms. Ann Med 34(3): 217-24, (2002).
van der Kraan PM and van den Berg WB. Anabolic and destructive mediators in osteoarthritis. Curr Opin Clin Nutr Metab Care,3:205-211, 2000.
Verdu et al., Nat cell Biol 1:500-505 (1999).
Ward SG, Finan P. Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents. Curr Opin Pharmacol. Aug;3(4):426-34, (2003).
Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo- oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A 96, 7563-7568, (1999).
Wong BR, et al. Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opin Investig Drugs 13:743-762, 2004.
Yajima, H., Ikeshima, E., Shiraki, M., Kanaya, T., Fujiwara, D., Odai, H., Tsuboyama-Kasaoka, N., Ezaki, O., Oikawa, S., and Kondo, K. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. J Biol Chem, 279: 33456-33462, (2004).
Yamada, T., Taniguchi, T., Yang, C., Yasue, S., Saito, H. & Yamamura, H. Association with B-cell antigen cell antigen receptor with protein-tyrosine kinase-P72(Syk) and activation by engagement of membrane IgM. Eur. J. Biochem. 213: 455-459,(1993).
Yamauchi, T., J. Kamon, et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 276(44): 41245-54, (2001).
Yang, W. S., W. J. Lee, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 86(8): 3815-9, (2001).
International Search Report for corresponding PCT Application No. PCT/US2007/14372, 5 PP.
Written Opinion for corresponding PCT Application No. PCT/US2007/14372, 5 PP.
International Search Report for related PCT Application No. PCT/US2007/014373.
Written Opinion for related PCT Application No. PCT/US2007/014373.
Miranda et al. Antiproliferative and Cytotoxic Effects of Prenylated Flavanoids from hops (Humulus lupulus) in human cancer cell lines. Food and Chemical Toxicology, 1999, 27, pp. 271-285.
Machine Translation of DE19939350 obtained from EPO on Sep. 4, 2008.
Zips et al. New anticancer agents: in vitro and in vivo evaluation. In Vivo. 2005, 19, pp. 1-8.
Wu et al., Phenolic antioxidants from the heartwood of Acacia confusa. J. Agric. Food checm. 2005, 53, pp. 5917-5921.
Kaur, Journal of Ethnopharmacology, May 2005, vol. 99, pp. 353-360.
Kamb, Nature Reviews: Drug Discovery 2005, vol. 4, pp. 16-165.
www.dfa.gov/fdac/special/testtubetopatient/studies.html-accessed Sep. 2008.
Remington's Pharmaceutical Sciences, 15th edition, Mack Publishing Co., Chapter 75, pp 1365-1367 (9175), 1975.
Gerhauser, et al., Cancer chemopreventive Activity of Xanthohumol, a Natural Product from Hop, Molecular Cancer Therapeutics, vol. 1., No. 11, pp. 959-969, Abstract and Figs 1-5, 2002.
International Search Report for Corresponding PCT Application No. PCT/US07/14412, 2 pp.
Written Opinion for Corresponding PCT Application No. PCT/US07/14412, 4 pp.
International Search Report for corresponding PCT Application No. PCT/US2007/14380, 2 PP.
Written Opinion for corresponding PCT Application No. PCT/US2007/14380, 4 PP.
Database Derwent ACC-No. 2005-761614 on STN. “Ayurvedic medicinal composition for treating uterus”. Acharya, H. IN 200101228 II, Mar. 11, 2005, Derwent English Abstract.
Babish John G.
Bland Jeffrey S.
Desai Anu
Hall Amy
Konda Veera
McDermott Will & Emery LLP
Meller Michael V
Metaproteomics, LLC
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