Xanthine modulators of metabolism of cellular P-450

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514265, 544229, 544267, 544268, 544269, 544270, 544271, A61K 3152, C07D47310, C07D47306

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active

060750294

ABSTRACT:
A new class of xanthine compounds, variously substituted at the 1, 3, 7 and 8 positions, is characterized by an ability to modulate the activity of key enzymes involved in drug metabolism. These compounds generally are useful in affecting drug metabolism and, particularly, in extending the circulating half-life of compounds that are metabolized via P-450-mediated pathways.

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