Xanthine derivatives

Details Xanthine derivatives Xanthine derivatives

1992-02-24

1994-03-01

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544225, 544226, 544273, C07D47302, A61K 3152

Patent

active

052907821

ABSTRACT:
Novel xanthine compounds represented by the following formula: ##STR1## wherein each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents; ##STR2## where ----- represents a single bond or a double bond; Y represents a single bond or alkylene, n represents 0 or 1, each of W.sup.1 and W.sup.2 independently represents hydrogen, lower alkyl or amino, Z represents --CH.sub.2 -, --O--, --S-- or --NH--; represents ##STR3## each of R.sup.1 and R.sup.2 independently represents hydrogen, lower alkyl, allyl or propargyl; and R.sup.3 represents hydrogen or lower alkyl, and when Q represents the groups other than ##STR4## each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;
provided that when Q is ##STR5## then R.sup.1 R.sup.2 and R.sup.3 are not
simultaneously methyl; and pharmaceutically acceptable salts thereof have a diuretic effect, a renal-protecting effect and a bronchodilatory effect.

REFERENCES:
patent: 4548820 (1985-10-01), Regnier et al.
patent: 4603203 (1986-07-01), Furukawa et al.
patent: 4925847 (1990-05-01), Hofer
Chemical Abstracts, vol. 63, No. 13, Dec. 20, 1965 p. 18120, Column 2, Abstract No. 18120d.
The Merck Index, (1983), 10th ed. 9110.
Castagnino, et al, Tetrahedron Lett., (1986) 27, 6337.
Goodsell, et al., J. Med. Chem., (1971) vol. 14, 1202.
Kellett, et al., Br. J. Pharmacol., (1989), vol. 96, 31P.
Kellett, et al., Br. J. Pharmacol, (1989), vol. 97, 502P.
Coulson, et al., J. Pharmacol. Exp. Ther. (1989), vol. 248(2), 589.
Bruns, et al., "Adenosine and Adenine Nucleotides: Physiology and Pharmacology," (1988), p. 39 (D. M. Paton, Ed).
Martinson, et al., Mol. Pharmacol., (1987), vol. 31, 247.
Shamin et al., J. Med. Chem., (1989) vol. 32, 1231.
Jacobson, et al., Biochem. Pharmacol., (1988) vol. 37, 3653.
Shamim, et al., J. Med Chem., (1989), vol. 32, 1231.
Jacobson, et al., J. Med. Chem., (1989), vol. 32, 1873.
Katsushima, et al., J. Med. Chem., (1990), vol. 33, 1906.

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