Xanthine derivatives

Details Xanthine derivatives Xanthine derivatives

1995-06-07

1998-05-26

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544269, 544270, 544273, C07D47306

Patent

active

057567352

ABSTRACT:
The present invention relates to novel xanthine derivatives of the formula (I) which are selectively antagonistic to an adenosine A.sub.2 receptor, and pharmaceutically acceptable salts thereof. Formula (I): ##STR1## In the formula, R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a propyl group, a butyl group or an allyl group; R.sup.3 represents a hydrogen atom or a lower alkyl group; Y.sup.1 and Y.sup.2 are the same or different and each represents a hydrogen atom or a methyl group; and Z represents a substituted or unsubstituted phenyl group, a pyridyl group, an imidazolyl group, a furyl group or a thienyl group.

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patent: 5270316 (1993-12-01), Suzuki
Trivedi et al., Structure-Activity Relationships of Adenosine A1 and A2 Receptors, Adenosine and Adenosine Receptors, Williams ed. (1990) Ch.3, 57-103.
Erickson et al., J. Med. Chem., vol. 34, No. 4 (1991) 1431:5.
Kaupp et al., Chem. Ber. vol. 119 (1986) 1525:39.
Lugovkin, Chem Abs 60, 1741g (1963).
Kalu, Bone and Mineral 14, 175-187 (1991).
Jacobson, J Med Chem 35, 407 (1992).

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