Xanthine derivatives

Details Xanthine derivatives Xanthine derivatives

1986-04-25

1989-11-07

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544272, 544270, 514265, C07D47306, A61K 3152

Patent

active

048792969

ABSTRACT:
The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for conditions associated with the cell surface effects of adenosine.

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Trends in Pharm. Sci., Jan., 1980, pp. 129-132.
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Bruns et al., Proc. Nat'l. Acad. Sci, U.S.A., vol. 80, pp. 2077-2080, Apr. 1983, Neurobiology, Adenosine Receptor Binding: Structure-Activity Analysis Generates Extremely Potent Xanthine Antagonists.
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