Xanthenylamide handle for use in peptide synthesis

Details Xanthenylamide handle for use in peptide synthesis Xanthenylamide handle for use in peptide synthesis

1990-08-31

1992-05-26

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548364, 548358, C07D31188

Patent

active

051170094

ABSTRACT:
The preparation and properties of xanthenylamide handles for use in peptide synthesis is disclosed. The compounds, Fmoc-9H-2-alkyleneoxycarboxy-xanthene-9-amines, are used as peptide handles in the solid phase synthesis of peptide amides.

REFERENCES:
Caciagli, V. et al., Proceeding of the European Peptide Symposium (Sep. 1990), Abstract p. 97.
Albericio, F. et al., J. Organ. Chem. 55:3730-3743 (1990).
P. Sieber, Tetrahedron Letters 28:2107-2110 (1987).
Barany et al., Int. J. Peptide Protein Res. 30:703-739 (1987).

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