κ opioid receptor agonist comprising...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S179000, C548S180000

Reexamination Certificate

active

07112598

ABSTRACT:
A compound or a salt thereof having the following formulawherein R1is acyl, R2is hydrogen, halogen, unsubstituted alkyl or alkyl substituted by halogen; R3is halogen or alkoxy; R4is cycloalkyl, unsubstituted alkyl or alkyl substituted by cycloalkyl, aryl or hydroxyl or an ester thereof or alkoxy; R5is hydroxyl or an ester thereof, alkoxy or alkoxyalkyl; or R4and R5are bonded with each other to form a pyrrolidine ring substituted by hydroxyl or an ester thereof, alkoxy or alkoxyalkyl; R6is hydroxyl or an ester thereof, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkoxy, mercapto or alkylthio; and A1and A2, are the same or different, and are alkylene, provided that (i) when R4and R5are bonded to each other to form the pyrrolidine ring substituted by hydroxyl or an ester thereof, R2is halogen; (ii) when R4and R5are bonded to each other to form the pyrrolidine ring substituted by alkoxyalkyl, R2is hydrogen; (iii) when R6is hydroxyl or an ester thereof, R4is isopropyl.

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