δ-amino-γ-hydroxy-ω-aryl-alkanoic acid...

Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...

Reexamination Certificate

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C554S061000, C554S065000, C564S155000, C564S164000, C514S558000, C514S563000, C514S616000, C514S620000

Reexamination Certificate

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07851642

ABSTRACT:
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I)and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

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Wood et al, Biochemical and Biophysical Research Communications 308, pp. 698-705, Structure-based design of aliskiren, a novel orally effective rennin inhibitor. (2003).
Goeschke et al. Bioorganic 8 Medicinal Chemistry Letters, vol. 7, No. 21, pp. 2735-2740, Design and Synthesis of Novel 2.7-Dialkyl. Substituted 5(S)-Amino-4(S)-H-y˜˜-8-Phenyl-Octanecarboxamides as in Vitro Potent Peptidomeimetic inhibitors of Human Renin, (1997).
Rahuel et al, Chemistry & Biology, 2000, vol. 7, No. 7, pp. 493-504.

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