β-substituted β-aminoethyl phosphonate derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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Details

C546S022000, C546S024000, C514S089000, C514S256000, C514S406000, C544S243000, C548S375100

Reexamination Certificate

active

06872711

ABSTRACT:
The present invention relates to novel β-substituted-β-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

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patent: 6060464 (2000-05-01), Nguyen et al.
patent: 6117873 (2000-09-01), Acklin et al.
patent: 6303784 (2001-10-01), Nguyen et al.
patent: 2158517 (1995-09-01), None
patent: 07059765 (1995-02-01), None
patent: PCTGB97/03479 (1997-12-01), None
patent: PCTEP97/07192 (1997-12-01), None
Surpak et al.; “Investigation on antibacterial activity of some new aminophosphinic and aminophosphonic complexons,”Pharmazie,1981:36:782-783.
Co-Pending U.S. application No. 09/963,900, by H. T. Phan et al., field Sep. 26, 2001.
Karimov et al., Necleophilic Addition of Amines to Dialkyl 1-Phenylethenyl-Phosphonate, J. Gen Chem. USSR 59:904-905, 1989.
Ing, “The Pharmacology of Homolous Series,” pp. 306-309, In: Progress in Drug Research, Ed. Jucker, Birkhaeuser verlag, vol. 7. 1964.

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