β-Secretase variant

Details β-Secretase variant β-Secretase variant

2007-11-06

2007-11-06

Swope, Sheridan L. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S320100, C435S252300, C435S252330, C435S325000, C435S254100, C435S070100, C435S071100

Reexamination Certificate

active

10838854

ABSTRACT:
The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to inhibit the catabolism or sequential cleavage of amyloid beta precursor protein (APP) by sequential cleavage of APP by beta secretase and gamma secretase.

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