β-secretase enzyme compositions and methods

Details β-secretase enzyme compositions and methods β-secretase enzyme compositions and methods

2006-09-19

2006-09-19

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C536S023200, C536S023400, C435S069100, C435S320100, C435S252330, C435S348000, C435S254200, C435S325000, C435S252300, C530S350000, C530S412000, C530S387300

Reexamination Certificate

active

07109017

ABSTRACT:
Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.

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