Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2006-08-08
2006-08-08
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S219000, C435S069200, C424S094300
Reexamination Certificate
active
07087399
ABSTRACT:
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.
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Vassar R. et al, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the new transmembrane aspartic protease BACE, Science, 1999, 286, 735-741.
Farzan M. et al, BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid—beta precursor protein, Proc. Natl. Acad. Sci. USA, 2000, 97, 9712-9717.
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Cordell Barbara
Hyslop Paul Andrew
Johnstone Edward Marion
Little Sheila Parks
Liu Yu-Wang
Morrison & Foerster / LLP
Prouty Rebecca E.
Scios Inc.
Walicka Malgorzata
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