β-secretase and modulation of β-secretase activity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Reexamination Certificate

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C435S219000, C435S069200, C424S094300

Reexamination Certificate

active

07087399

ABSTRACT:
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.

REFERENCES:
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patent: 6162630 (2000-12-01), Powell et al.
patent: 0 85544 (1998-01-01), None
patent: WO 00/58479 (2000-10-01), None
Vassar R. et al, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the new transmembrane aspartic protease BACE, Science, 1999, 286, 735-741.
Farzan M. et al, BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid—beta precursor protein, Proc. Natl. Acad. Sci. USA, 2000, 97, 9712-9717.
Wolfe M., Secretase targets for Alzheimer's disease: identification and therapeuthic potential, J. Med. Chem., 2001, 44, 2039-2060.

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