β-peptoids with antimicrobial activity

Details β-peptoids with antimicrobial activity β-peptoids with antimicrobial activity

2007-12-11

2007-12-11

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

11311097

ABSTRACT:
The present invention relates to beta-peptoids with antimicrobial activity. The present invention also relates to methods of producing β-peptoids. The antimicrobial β-peptoids of the invention are useful in pharmaceutical, healthcare, medical device, industrial, food, agricultural, and personal care applications.

REFERENCES:
Tossi et al., “Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity,” Eur. J. Biochem., 1997, 250, 549-58.
Jean-Luc Fauchere et. al., Differential Protection and Selective Deprotection in Peptide Synthesis, The Peptides, 1981, pp. 203-253, vol. 3.
Bruce C. Hamper et. al., Solid Phase Synthesis of B-Peptoids: N-Substituted B-Aminopropionic Acid Oligomers, J. Org. Chem., 1998, pp. 708-718, vol. 63.
Sankar Chatterjee et. al., Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I, J. Med. Chem., 1997, pp. 3820-3828, vol. 40.
Rozalyn A. Simon et. al., One-Bead-One-Compound Library of End-Capped Dipeptides and Deconvolution by Microflow NMR, J. Comb. Chem., 2005, pp. 697-702, vol. 7.

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