Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-16
2006-05-16
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S200000, C540S360000
Reexamination Certificate
active
07045515
ABSTRACT:
Novel β-lactam compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof which are useful as serum cholesterol-lowering agents:(I) wherein A1, A3and A4represent each hydrogen, halogen C1-5alkyl, C1-5alkoxy, —COOR1, a group represented by the following general formula (b): (b) wherein R1represents hydrogen or C1-5alkyl, or a group represented by the following general formula (a): (a) wherein R2represents —CH2OH, —CH2OC(O)—R1or —CO2—R1; R3represents —OH or —OC(O)—R1; R4represents —(CH2)kR5(CH2)1-wherein K and 1 are each 0 or an integer of 1 or above provided k+1 is an integer of not more than 10; and R5represents a single bond, —CH═CH—, —OCH2—, carbonyl or —CH(OH)—; provided that at least one of A1, A3and A4is a group represented by the above formula (a); A2represents C1-5alkyl, C1-5alkoxy, C1-5alkenyl, C1-5hydroxyalkyl or C1-5carbonylalkyl; and n, p, q and r are each an integer of 0, 1 or 2.
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Noda Atsushi
Ohno Akira
Tomiyama Hiroshi
Yokota Masayuki
Berch Mark L.
Kotobuki Pharmaceutical Co. Ltd.
Sherman & Associates
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