β-cyclodextrin derivatives as antibacterial agents

Details β-cyclodextrin derivatives as antibacterial agents β-cyclodextrin derivatives as antibacterial agents

2006-01-27

2010-06-15

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S046000

Reexamination Certificate

active

07737132

ABSTRACT:
The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of β-cyclodextrin (β-CD), which is a cyclic molecule comprising seven D-glucose units.

REFERENCES:
patent: 4247535 (1981-01-01), Lewis et al.
patent: 4258180 (1981-03-01), Lewis et al.
patent: 5250520 (1993-10-01), Kurita et al.
patent: 5585216 (1996-12-01), Baur et al.
patent: 5599912 (1997-02-01), Rodell et al.
patent: 5728823 (1998-03-01), Reuscher et al.
patent: 5739121 (1998-04-01), Wiebe et al.
patent: 5760017 (1998-06-01), Djedaini-Pilard et al.
patent: 5800602 (1998-09-01), Baur et al.
patent: 5821349 (1998-10-01), Djedaini-Pilard et al.
patent: 5834446 (1998-11-01), Dow et al.
patent: 5959089 (1999-09-01), Hanessian et al.
patent: 6042723 (2000-03-01), Duval et al.
patent: 6180356 (2001-01-01), London et al.
patent: 6632748 (2003-10-01), Yim et al.
patent: 6716827 (2004-04-01), Roselli et al.
patent: 6858723 (2005-02-01), Auzely-Velty et al.
patent: 7169477 (2007-01-01), Lyu et al.
patent: 2005/0059634 (2005-03-01), Venton et al.
patent: 2007/0021380 (2007-01-01), Wiebe et al.
patent: 2425663 (1975-12-01), None
patent: 3710569 (1988-05-01), None
patent: 4136325 (1993-05-01), None
patent: 19520967 (1996-12-01), None
patent: 19520989 (1996-12-01), None
patent: 1245628 (2002-10-01), None
patent: 2053399 (1994-07-01), None
patent: 2669535 (1992-05-01), None
patent: 2878853 (2006-06-01), None
patent: 2261740 (1993-05-01), None
patent: 49085015 (1974-08-01), None
patent: 50140476 (1975-11-01), None
patent: 51142088 (1976-12-01), None
patent: 52138580 (1977-11-01), None
patent: 53049089 (1978-05-01), None
patent: 03075634 (1991-03-01), None
patent: 06065307 (1994-03-01), None
patent: 10060006 (1998-03-01), None
patent: 2005290066 (2005-10-01), None
patent: WO95/17191 (1995-06-01), None
patent: WO97/49735 (1997-12-01), None
patent: WO99/50307 (1999-10-01), None
patent: WO01/40316 (2001-06-01), None
patent: WO01/83564 (2001-11-01), None
patent: WO01/98370 (2001-12-01), None
patent: WO02/077000 (2002-10-01), None
patent: WO2004/014959 (2004-02-01), None
patent: WO2004/085487 (2004-10-01), None
patent: WO2004/087768 (2004-10-01), None
patent: WO2005/042590 (2005-04-01), None
patent: WO2006/027631 (2006-03-01), None
patent: WO2006/075580 (2006-07-01), None
Croft et al , Tetrahedron 1983, 39(9), 1417-1474.
Salem et al, Intl. J. Pharm. 2003, 250, 403-414.
Athanassiou et al, Journal of Pharmacy and Pharmacology, 2003, 55, 291-300.
Croft et al., “Synthesis of Chemically Modified Cyclodextrins”, Tetrahedron, 39(9):1417-1474 (1983).
Castro-Hermida et al., “Treatment With B-Cyclodextrin of Natural Cryptosporidium Parvum Infections in Lambs Under Field Conditions”, International Journal for Parasitology, 21:1134-1137 (2001).
Salem et al., “Efficacies of Cyclodextrin-Complexed and Liposome-Encapsulated Clarithromycin Against Mycobacterium Avium Complex Infection in Human Macrophages”, International Journal of Pharmaceutics, 250:403-414 (2003).
Remington's Pharmaceutical Sciences, 18thEdition, ed. A. Gennaro, Mack Publishing Co., Easton, PA (1990).
Karginov et al., “Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities”; Antimicrobial Agents and Chemotherapy (2006), 50(11),3740-3753.
Wang et al., “Per-6-substituted-per-6-deoxy-β-cyclodextrins Inhibit the Formation of β-Amyloid Peptide Derived Soluble Oligomers”; Journal of Medicinal Chemistry (2004), 47(13),3329-3333.
Vizitiu et al. “Synthesis of Mono-facially Functionalized Cyclodextrins Bearing Amino Pendent Groups”; Journal of Organic Chemistry (1997), 62(25), 8760-8766.
Dixon et al., “Anthrax”, N. Engl. J. Med., 341(11):815-826 (1999).
Brossier et al., “Toxins ofBacillus anthracis”, Toxicon, 39:1747-1755 (2001).
Petosa et al., “Crystal Structure of the Anthrax Toxin Protective Antigen”, Nature, 385:833-838 (1997).
Karginov et al., “Treatment of Anthrax Infection With Combination of Ciproflaxacin and Antibodies to Protective Antigen ofBacillus anthracis”, FEMS Immun. Med. Microb., 40:71-74 (2004).
Baer et al., “Improved Preparation of Hexakis(6-deoxy)cyclomaltohexaose and Heptakis(6-deoxy)cyclomaltoheptaose”, Carbohydr. Res., 228:307-314 (1992).
Iwata et al., “Manufacture of Cyclodextrin Derivatives”, Jpn. Kokai Tokkyo Koho, 9pp. (1989).
Minora et al., “Amino Acid Polymers Containing Cyclodextrin in the Main Chain and their Preparation” Jpn. Kokai Tokkyo Koho 5pp., (1994).
Fukuhara et al., “Synthesis and characterization of the first pair of an unlocked and a locked self-inclusion complex from a permethylated alpha-cyclodextrin derivative”, Chem. Letters 32(6):536-537, (2003).
Kurita et al., “Cyclodextrin Derivatives”, Jpn. Kokai 7pp (1974).
Karginov et al., “β-Cyclodextrin derivatives that inhibit anthrax lethal toxin”; Bioorganic & Medicinal Chemistry, 14(1), 33-40 (2006).
Hoogenboom et al. “Synthesis of star-shaped poly(.vepsiln.-caprolactone) via ‘click’ chemistry and ‘supramolecular click’ chemistry”; Chemical Communications (Cambridge, United Kingdom) (38), 4010-4012 (2006).
Casas-Solvas et al. “Synthesis of Nitrogen-Functionalized β-Cycloaltrins”, Journal of Organic Chemistry, 69(25), 8942-8945 (2004).
Kraus et al. “A homologous series of persubstituted cyclodextrin amino acids:The quest for tubular self-assembly”, European Journal of Organic Chemistry, (19), 4060-4069 (2004).
Sallas et al. “A practical synthesis of amphiphilic cyclodextrins fully substituted with sugar residues on the primary face”, Chemical Communications (Cambridge, United Kingdom) (5), 596-597(2004).
Mourtzis et al. “Influence of Host's Substitution on the Orientation of the Guest: Pseudo-rotaxanes of Charged Cyclodextrins with Methyl Orange in Solution”; Supramolecular Chemistry, 16(8), 587-593 (2004).
Heck et al. “Heptakis-6-(5-methylene-thioureido-5′-methyl-2,2′-bipyridyl)-β-cyclodextrin: synthesis and metal complexation study”; Tetrahedron Letters, 44(8), 1533-1536 (2003).
Heck et al. “New scaffolds for supramolecular chemistry: upper-rim fully tethered 5-methyleneureido-5′-methyl-2,2′-bipyridyl cyclodextrins”; Chemistry—A European Journal, 8(11), 2438-2445(2002).
Reddy et al. “An efficient protocol for the reduction of azidocyclodextrins catalyzed by indium”; Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 41B(3), 645-646 (2002).
Velmurugan et al. “Optimization of the reversed-phase high-performance liquid chromatographic separation of the enantiomers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column”; Chromatographia, 56(¾), 229-232(2002).
Chen et al. “Synthesis and chromatographic properties of a novel chiral stationary phase derived from heptakis(6-azido-6-deoxy-2,3-di-O-phenylcarbamoylated)-β-cyclodextrin immobilized onto amino-functionalized silica gel via multiple urea linkages”; Journal of Chromatography, 950(1-2), 65-74 (2002).
Ng et al. Enantiomer separation of flavor and fragrance compounds by liquid chromatography using novel urea-covalent bonded methylated β-cyclodextrins on silica;Journal of Chromatography, 968(1-2), 31-40 (2002).
Wagner et al. “Heptakis-6-(5-methylene-ureido-5′-methyl-2,2′-bithiazolyl)-cyclomaltoheptaose as a new fluorescent poly-dentate ligand”; Tetrahedron Letters, 42(31), 5207-5209 (2001).
Ravoo et al. “Supramolecular tapes formed by a catanionic cyclodextrin in water”; Chemical Communications (Cambridge, United Kingdom), (9), 827-828 (2

Affiliated with

Also associated with

Rating

β-cyclodextrin derivatives as antibacterial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with β-cyclodextrin derivatives as antibacterial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and β-cyclodextrin derivatives as antibacterial agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4239752