β-Benzyloxyaspartate derivatives with amino group on...

Details β-Benzyloxyaspartate derivatives with amino group on... β-Benzyloxyaspartate derivatives with amino group on...

2007-06-14

2010-02-23

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C436S501000, C560S039000

Reexamination Certificate

active

07666906

ABSTRACT:
L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1):wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group,having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.

REFERENCES:
patent: 6147113 (2000-11-01), Shimamoto et al.
patent: 0658539 (1995-06-01), None
patent: 0844234 (1998-05-01), None
Arriza J.L. et al. “Functional Comparisons of Three Glutamate Transporter Subtypes Cloned From Human Motor-Cortex” J. of Neuroscience, vol. 14, No. 9, Sep. 1, 1994.
Lebrun B. et al. “New Beta-Hydroxyasparate Derivatives . . . Glutamate/Asparate Transporter” J. of Biological Chemistry, vol. 272, No. 33, Aug. 15, 1997, pp. 20336-20339.
Shimamoto, et al. DL-threo-B-Benzyloxyaspartate, A Potent Blocker of Excitatory amino acid transporters. Molecular Pharmacology, 1998, vol. 53(2), pp. 195-201.

Affiliated with

Also associated with

Rating

β-Benzyloxyaspartate derivatives with amino group on... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with β-Benzyloxyaspartate derivatives with amino group on..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and β-Benzyloxyaspartate derivatives with amino group on... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4164923