β-alanine derivatives and the use thereof

Details β-alanine derivatives and the use thereof β-alanine derivatives and the use thereof

2007-10-23

2007-10-23

Richter, Johann (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S155000, C564S156000, C564S161000, C564S163000, C562S400000, C562S405000, C562S465000, C562S492000

Reexamination Certificate

active

10515653

ABSTRACT:
A compound of the general formula (I)(wherein the symbols are as defined in the description), or a prodrug or a salt thereof.This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urinary system disease (symptom with prostatic hypertrophy or neurogenic bladder dysfunction disease, symptom to be caused by spinal cord neoplasm, nucleous hernia, spinal canal stenosis or diabetes, lower urinary tract symptom (for example, occlusion disease of lower urinary tract), inflammatory disease of lower urinary tract, polyuria), carcinoma association disease (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi's sarcoma, leucemia and carcinomatous infiltration transition), proliferative disease (disorder with aberrant angiogenesis, artery obstruction and pulmonary fibrosis), inflammation/immune system disease (psoriasis, nephropathy, hepatitis and pneumonitis symptom), disease by secretion fault (Sjogren syndrome) or brain association disease (brain infarction, cerebral apoplexy and brain or peripheral neuropathy).

REFERENCES:
patent: 1 550 461 (2005-07-01), None
patent: 2002-212070 (2002-07-01), None
patent: WO 01/60819 (2001-08-01), None
patent: WO 01/71022 (2001-09-01), None
patent: WO 02/092068 (2002-11-01), None

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