Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2006-09-12
2006-09-12
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S305000, C564S337000, C564S220000, C546S141000, C546S153000, C514S306000, C514S307000, C514S649000, C514S650000, C514S630000
Reexamination Certificate
active
07105701
ABSTRACT:
Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
REFERENCES:
patent: 3211792 (1965-10-01), Osbond et al.
patent: 3217039 (1965-11-01), Humber
patent: 3875233 (1975-04-01), Bastian et al.
patent: 4021485 (1977-05-01), Schromm et al.
patent: 4304721 (1981-12-01), Fahrenholtz et al.
patent: 4587046 (1986-05-01), Goodman et al.
patent: 5736546 (1998-04-01), Kawashima et al.
patent: 6162807 (2000-12-01), Kochanny et al.
patent: 6268533 (2001-07-01), Gao et al.
patent: 6362371 (2002-03-01), Moran et al.
patent: 6541669 (2003-04-01), Moran et al.
patent: 6576793 (2003-06-01), Moran et al.
patent: 6593497 (2003-07-01), Choi et al.
patent: 6683115 (2004-01-01), Moran et al.
patent: 6713651 (2004-03-01), Moran et al.
patent: 6919482 (2005-07-01), Moran et al.
patent: 2003/0087307 (2003-05-01), Moran et al.
patent: 2004/0188080 (2004-09-01), Moran et al.
patent: 550 768 (1974-06-01), None
patent: 1158 082 (1963-11-01), None
patent: 1215729 (1966-05-01), None
patent: 3306160 (1984-08-01), None
patent: 0 145 067 (1985-06-01), None
patent: 0 196 849 (1986-10-01), None
patent: 0 233 686 (1987-08-01), None
patent: 1040724 (1966-09-01), None
patent: 1 394 542 (1975-05-01), None
patent: 10152460 (1998-06-01), None
patent: WO 96/19987 (1996-07-01), None
patent: WO 98/21175 (1998-05-01), None
patent: WO 99/64035 (1999-12-01), None
Alvarez et al., “Structure-Activity Relationships among Di- and Tetramine Disulfides Related to Benextramine”, J. Med. Chem., vol. 30, No. 7, pp. 1186-1193 (1987).
Auterhoff et al., “Lehrbuch der Pharmazeutischen Chemie”, 12th Edition.Stuttgart:Wiss. Verl.-Ges. pp. 646-648 (1991)—in German with English abstract.
Barnes, “Current Therapies for Asthma, Promise and Limitations”, Chest, 111/2, pp. 17S-26S (1997).
Bastian et al., “Carbocyclic compounds”, (5128p), Chemical Abstracts, vol. 79, pp. 433-434 (1973).
Bastian, “Carbocyclic compounds”, (104935r), Chemical Abstracts, vol. 79, pp. 400 (1973).
Carrithers et al., “Synthesis and characterization of bivalent peptide ligands targeted to G-protein-coupled receptors”, Chemistry & Biology, vol. 3, No. 7, pp. 537-542 (1996).
Colella et al., “N,N'-Bis[2-(4-hydroxyphenyl)ethyl]polymethylene-diamines” (126069d), Chemical Abstracts, vol. 79, pp. 371-372 (1973).
Hoffman et al., “Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists (Chapter 10)”, Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, pp. 199-216 (1996).
Howe et al., “β-Adrenergic Blocking Agents. VII. 2-(1,4-Benzodioxanyl) and 2-Chromanyl Analogs of Pronethalol [2-Isopropylamino-1-(2-naphthyl)ethanol]”, Journal of Med Chem, vol. 13, No. 2, pp. 169-176 (1970).
Jack, “A way of looking at agonism and antagonism: Lessons from salbutamol, salmeterol and other β-adrenoceptor agonists”, Br. J. clin. Pharmac., 31, pp. 501-514 (1991).
Kierstead et al., “β1Selective Adrenoceptor Antagonists. 1. Synthesis and β-Adrenergic Blocking Activity of a Series of Binary (Aryloxy) propanciamines”, J. Med. Chem., 26, pp. 1561-1569 (1983).
Kizuka et al., β-Adrenoceptor Antagonist Activity of Bivalent Ligands. 1. Diamide Analogues of Practolo, J. Med. Chem., 30, pp. 722-726 (1987).
Kusiak et al., “Two β-Adrenergic Pharmacophores on the same molecule, A set of agonist-antagonist combinations”, Biochemical Pharmacology, vol. 36, No. 2, pp. 269-275 (1987).
Machin et al., “β1-Selective Adrenoceptor Antagonists. 2. 4-Ether-Linked Phenoxypropanolamines”, J. Med. Chem., vol. 26, pp. 1570-1576 (1983).
Mentrup et al., “N,N′-Bis[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1,6-hexanediamine sulfate”, Chemical Abstracts, vol. 82, Jan. 6-Jan. 27 (abstracts 1-25504) 1975.
Milecki et al., “Carbostyril Derivatives Having Potent β-Adrenergic Agonist Properties”, J. Med. Chem., 30, pp. 1563-1568 (1987).
Murakami et al., “a-(Aminomethyl)benzyl alcohol derivatives”, Chemcial Abstracts 79: 126063X (1973).
Pinder et al., “Hexoprenaline: A Review of its Pharmacological Properties and Therapeutic Efficacy with Particular Reference to Asthma”, Drugs 14: 1-28 (1977).
Pitha et al., “β-Adrenergic Antagonists with Multiple Pharmacophones: Persistent Blockade of Receptors”, J. Med. Chem., 26, pp. 7-11 (1983).
Pitha et al., “Macromolecular β-adrenergic antagonists discriminating between receptor and antibody”, Proc. Natl. Acad. Sci. USA, vol. 77, No. 4, pp. 2219-2223 (1980).
Portoghese, “The Role of Concepts in Structure-Activity Relationship Studies of Opioid Ligands”, J. Med. Chem., vol. 35, No. 11 (1992).
Schmid et al., “Bis(alkanolamine) derivatives”, Chemical Abstracts , vol. 63 (1965).
Schromm et al., “Polymethylenediamines”, Chemical Abstracts (57999x), vol. 78, p. 485 (1973).
Siegel et al., “The use of high-throughout synthesis and purification in the preparation of a directed library of adrenergic agents”, Molecular Diversity, 3, pp. 113-116 (1998).
Stormann et al., “Die Stimulierende Wirksamkeit von Hexoprenalin auf verschiedene sympathische β-Rezeptoren”, Arzneimittel-Forschung, 23(1), pp. 30-38 (in German with English abstract) (1973).
Wismayr et al., “N,N′-Bis-[2,3,4-dihydroxyphenyl)-2-hydroxyethyl]-hexamethylenediamine, its optically active form and its salts”, Chemical Abstracts (42149p), vol. 74, pp. 333 (1971).
Wismayr et al., “N,N′-Bis[2,3,4- dihydroxyphenyl)-2-hydroxyethyl]-hexamethylenediamine and its salts”, Chemical Abstracts (35405m), vol. 75, pp. 457-458 (1971).
Wissmayr et al., “N,N′-bis[2,(3′,4′-Dihydroxyphenyl)-2-hydroxyethyl]-hexamethylenediamine”, Chemical Abstracts (14096s), vol. 76, pp. 347 (1972).
Yokoi et al., “The Development of a Radioimmunoassay for Formoterol”, Life Sciences, vol. 33, pp. 1665-1672 (1983).
Zoelss et al., “Broncholytic N,N′-bis[2-(3,4-dihydroxyphenyl)-2hy-droxyethyl]diaminoalkanes”, Chemical Abstracts (87613b), vol. 74, pp. 406 (1971).
Choi Seok-Ki
Moran Edmund J.
Cohen Joyce G.
Hagenah Jeffrey A.
Kumar Shailendra
Saxon Roberta P.
Theravance Inc.
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