β 1,4-N-acetylgalactosaminyl transferases from C. jejuni

Details β 1,4-N-acetylgalactosaminyl transferases from C. jejuni β 1,4-N-acetylgalactosaminyl transferases from C. jejuni

2007-07-03

2007-07-03

Swope, Sheridan (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S069700, C435S252330

Reexamination Certificate

active

10962235

ABSTRACT:
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example,Campylobacterspecies, includingC. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.

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