Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-12-26
2006-12-26
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S249000, C514S252020, C514S255050, C514S272000, C544S238000, C544S295000, C544S297000, C544S353000
Reexamination Certificate
active
07153862
ABSTRACT:
The present invention relates to novel alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.
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Askew Ben C.
Breslin Michael J.
Duggan Mark E.
Hutchinson John H.
Meissner Robert S.
Daniel Mark R.
Merck & Co. , Inc.
Shatynski Patricia A.
Truong Tamthom N.
Wilson James O.
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