α-tocopherol transport protein knockout animal

Details α-tocopherol transport protein knockout animal α-tocopherol transport protein knockout animal

2006-01-03

2006-01-03

Woitach, Joseph (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S021000

Reexamination Certificate

active

06982362

ABSTRACT:
The present invention provides a knockout animal artificially modified to inhibit α-TTP gene expression. This animal is useful as a tool for understanding mechanisms for the development of familial isolated vitamin E deficiency and other diseases induced by oxidative stress (e.g., arteriosclerosis, diabetes). It is also useful as a tool for developing a therapeutic agent for these diseases.

REFERENCES:
Leonard, 1995, Immunological Reviews, vol. 148, pp. 98-113.
Moens, 1993, Development, vol. 119, pp. 485-499.
Griffiths, 1998, Microscopy Research and Technique, vol. 41, pp. 344-358.
Hammer, 1990, Cell, vol. 63, 1099-1112).
Mullins, 1990, Nature, vol. 344, 541-544.
Mullins, 1989, EMBO J., vol. 8, pp. 4065-4072.
Taurog, 1988, Jour. Immunol., vol. 141, pp. 4020-4023.
Wall, 1996, Theriogenology, vol. 45, pp. 57-68.
Overbeek, 1994, “Factors affecting transgenic animal production,” Transgenic animal technology, pp. 96-98.
Mullins, 1996, J. Clin. Invest., vol. 98, pp. S37-S40.
Arai, 1998, FASEB Journal, vol. 12 pp. A658).
Capecchi, 1994, Scientific American, Mar. 1994, pp. 52-59.
Campbell and Wilmut , 1997, Theriogenology, vol. 47, pp, 63-72.
Robins, 1981, Cell, vol. 23, pp. 29-39.
Cavalier, 1998, Am J Hum Genet, vol. 62, p. 301-310.
Thomas, 1993, J Anat, vol. 183, pp. 451-461.
http://www.dddmag.com/Glossary.aspx?RPTID=KWSRCH&SEARCHMETHOD=WORD&SEARCHWORD=Knockout.
Jones, Jeffrey M. et al., “Human Embryonic Stem Cell Technology,” Seminars inReproductive Medicine, vol. 18, No. 2, pp. 219-223 (2000).
Ledermann, B., “Special Review Series—Gene Manipulation and Integrative Physiology, Embryonic Stem Cells and Gene Targeting,”Experimental Physiology, vol. 85, No. 6, pp. 603-613 (2000).
Prelle, Katja et al., “Establishment of Pluripotent Cell Lines from Vertebrate Species—Present Status and Future Prospects,”Cells Tissues Organs, vol. 165, pp. 220-236 (1999).
“Embryonic Stem Cell Research—Still at the Starting Gate,”The Lancet(Oncology), p. 523 (2001).
Sato, Y. et al., “Primary Structure of α-Tocopherol Transfer Protein From Rat Liver:Homology with Cellular Retinaldehyde-Binding Protein”, The Journal of Biological Chemistry, vol. 268, No. 24, pp. 17705-17710, (1993).
Arita, M. et al., “Human α-Tocopherol Transfer Protein: cDNA Cloning, Expression and Chromosomal Localization”, Biochemistry Journal, vol. 306, No. 2, pp. 437-443, (1995).
Ouahchi, K. et al., “Ataxia with Isolated Vitamin E Deficiency is Caused by Mutations in the α-Tocopherol Transfer Protein”, Nature Genetics, vol. 9, No. 2, pp. 141-145, (1995).
Mansour, S.L. et al., “Disruption of the Proto-Oncogene int-2 in Mouse Embryo-Derived Stem Cells: a General Strategy for Targeting Mutations to Non-Selectable Genes”, Nature, vol. 336, No. 24, pp. 348-352, (1998).
Abstracts From the 72ndScientific Sessions, Circulation, vol. 100, No. 18, Supp.[S], pp. 231, (Nov. 2, 1999).
Arita, Makoto et al., “α-Tocopherol Transfer Protein Stimulates the Secretion of α-Tocopherol from a Cultural Liver Cell line Through a Brefeldin A-insensitive Pathway,”Proc. Natl. Acad. Sci. USA, vol. 94, pp. 12437-12441 (1997).
Rudmann, Daniel G. et al., “Utilization of Genetically Altered Animals in the Pharmaceutical Industry,”Toxicologic Pathology, vol. 27, No. 1, pp. 111-114 (1999).
Traber, Maret G. et al., “Molecular Mechanisms of Vitamin E Transport,”Annu. Rev. Nutr., vol. 19, pp. 343-355 (1999).
Copy of European Search Report, dated Oct. 13, 2004.

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