α-glucosidase inhibitors from lichens

Details α-glucosidase inhibitors from lichens α-glucosidase inhibitors from lichens

2011-01-11

2011-01-11

Wang, Shengjun (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

active

07867989

ABSTRACT:
This invention is directed to a novel method for the inhibition of α-glucosidase enzyme and thus treating diabetes, viral infections, fungal infections, autoimmune function disorders and obesity using compounds derived as lichen metabolites; more specifically, this includes the therapeutic applications of methylorsellinate (2,4-dihydroxy-6-methylbenzoate, Compound I), methyl-β-orinolcarboxylate (2,4-dihydroxy-3,6-dimethylbenzoate, Compound II) and zeorin (6,22-hopanediol, Compound III).

REFERENCES:
patent: 4536474 (1985-08-01), Yamamoto et al.
Ageta et al. “Fern constituents. on the origin of a Formosan native drug “Tie-Yu-san” and its triterpenoid constituents,” Shoyakugaku Zasshi, 1981, vol. 35, No. 4, pp. 259-261. CAPLUS abstract, AN 1982:411686.

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