α-galactosidases and methods for making and using them

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C435S018000, C435S069100, C536S023200, C530S350000

Reexamination Certificate

active

06987016

ABSTRACT:
The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increased pH and temperature.

REFERENCES:
patent: 5686294 (1997-11-01), Sogabe et al.
patent: 5958751 (1999-09-01), Murphy et al.
patent: 6057098 (2000-05-01), Buechler et al.
patent: 0 606 008 (1994-07-01), None
patent: 0 687 732 (1995-12-01), None
Witkowski et al. , Biochemistry 38:11643-11650, 1999.
Bork , Genome Research, 10:348-400, 2000.
Broun et al. , Science 282:1315-1317, 1998.
Van de Loo et al. , Proc. Natl. Acad. Sci. 92:6743-6747, 1995.
Kawarabayasi et al. , PIR accession No. E71144, Aug. 14, 1998.
O.N. Dakhova, et al., “Cloning and Expression inEscherichia coliofThermotoga neapolitanaGenes Coding For Enzymes of Carbohydrate Substrate Degradation”,Biochemical and Biophysical Research Communications, Academic Press, Inc., Orlando, Florida, USA, vol. 194, No. 3, Aug. 16, 1993, pp. 1359-1364.
F,. Canganella et al., “Characterization of amylolytic and pullulytic enzymes from thermophilic archaea and from a newFervidobacteriumspecies”,Applied Microbiology and Biotechnology, Springer-Verlag, Berlin, Germany, vol. 42, No. 2/3, 1994, pp. 239-245.
GenBank Database Record NID g3236129 “Pyrococcus horikoshii OT3 genomic DNA, 287001-544000 nt. Position”, Submitted by Tanaka et al, Jul. 25, 1998.
Abaza, et al., “Effects of Amino Acid Substitutions Outside an Antigenic Site on Protein Binding to Monoclonal Antibodies of Predetermined Specificity Obtained by Peptide Immunization; Demonstration with Region 94-100 (Antigenic Site 3) of Myoglobin”,Journal of Protein Chemistry, vol. 11, No. 5, pp. 433-444, 1992.
Ngo, et al., “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox”,The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14, pp. 491-494, 1994.
Campbell, “General Properties and Applications of monoclonal antibodies”,Elsevier Science Publishers, section 1.1., pp. 1-32, 1984.
Li, et al., “β-endorphin omission analogs: Dissociation of immunoreactivity from other biological activities”,Proc. Natl. Acad. Sci., vol. 77, No. 6, pp. 3211-3214, Jun., 1980.
Lederman, et al., A Single Amino Acid Substitution in a Common African Allele of the CD4 Molecule Ablates Binding of the Monoclonal Antibody, OKT4,Mol. Immunology, vol. 28, No. 11, pp. 1171-1181, 1991.
Colman, “Effects of amino acid sequence changes on antibody-antigen interactions”,Research in Immunology, vol. 145, No. 1, pp. 33-36, 1994.
Koizumi, et al., “Isolation and characterization of novel heterogenous branched cyclomalto-oligosaccharides (cyclodextrins) produced by transgalactosylation with a-galactosidasse from coffee bean”,Carbohydrate Research, vol. 278, pp. 129-142, 1995.
Ishii, et al., “Human α-galactosidase gene expression: significance of two peptide regions encoded by exons 1-2 and 6”,Biochimica et Biophysica Acta, vol. 1204, pp. 365-270, 1994.
Sakka, et al., “Nucleotide Sequence ofthe Clostridium stercorarium xynAGene Encoding Xylanase A: Identification of Catalytic and Cellulose Binding Domains”,Biosci. Biotech Biochem., vol. 57, No. 2, pp. 273-277, 1993.
Keller, et al.,Thermococcus alcaliphilussp. nov., a new hypethermophilic archaeum growing on polysulfide at alkaline pHArch. Microbiol., vol. 164, pp. 390-395, 1995.
Seffernick, et al., “Melamine Deaminase and Atrazine Chrlorohydrolase: 98 Percent Identifical but Functionally Different”,Journal of Bacteriology, vol. 183, No .8, pp. 2405-2410, Apr., 2001.
Kawarabayasi, et al., GenEMBL accesion No. AP00002, Apr. 2000.
Verhees, et al., GenEMBL accession No. AF195244, Nov., 2000.
Carrington, et al., GenEMBL accession No. TBILTA124, Nov., 1991.

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