α-form or β-form crystal of acetanilide derivative

Details α-form or β-form crystal of acetanilide derivative α-form or β-form crystal of acetanilide derivative

2011-07-19

2011-07-19

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S370000

Reexamination Certificate

active

07982049

ABSTRACT:
To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide. The α-form crystal does not exhibit hygroscopicity and has stability such that it can be used as a medicine, and is useful for mass synthesis in the industrial production. The β-form crystal does not relatively exhibit hygroscopicity and is also useful as a production intermediate of the α-form crystal.

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International Search Report, for PCT/JP02/11217, dated Jan. 28, 2003.
Rouhi, Chemical and Engineering News, Feb. 24, 2003, pp. 32-35, especially p. 32.

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