Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Reexamination Certificate
2002-03-28
2008-03-25
Kam, Chih-Min (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
C530S327000, C530S324000, C530S855000, C514S013800, C514S014800, C435S007100, C424S009100, C536S023100
Reexamination Certificate
active
07348400
ABSTRACT:
This invention relates to novel α-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C—NH2in which Xaa1is G or D; Xaa3is proline, hydroxyproline or glutamine; each of Xaa2to Xaa8and Xaa11is independently any amino acid; Xaa9is proline, hydroxyproline or glutamine; Xaa10is aspartate, glutamate or γ-carboxyglutamate; Xaa11is optionally absent; and the C-terminus is optionally amidated, with the proviso that the peptide is not α-conotoxin Ep1 or α-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.
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Down John Geoffrey
Gayler Kenwyn Ronald
Keays David Anthony
Khalil Zeinab
Livett Bruce Grayson
Browdy and Neimark , P.L.L.C.
Kam Chih-Min
Livett Bruce Grayson
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