Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-10-09
2010-02-23
Carlson, Karen Cochrane (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C530S326000, C530S324000, C530S857000
Reexamination Certificate
active
07666840
ABSTRACT:
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
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Result 9, search in the Uniprot database on Jul. 24, 2009, alignment of instant SEQ ID No. 300 with the polypeptide of Lu et al., “Conopeptides from Conus striatus and Conus textile by cDNA cloning,” Peptides 20:1139-1144, 1999.
Cartier, GE et al., “A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors,” Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, Inc., vol. 271, No. 13, Mar. 29, 1996, pp. 7522-7528, XP-002170539.
Codignola, Agnese et al., “Alpha-Conotoxin Imperialis I Inhibits Nicotine-Evoked Hormone Release and Cell Proliferation in Human Neuroendocrine Carcinoma Cells,” Neuroscience Letters, vol. 206, No. 1, 1996, pp. 53-56, XP-002290023.
McIntosh, J.M. et al. (1999).Ann Rev Biochem68:59-88.
Hillyard David R.
Jones Robert M.
McIntosh J. Michael
Olivera Baldomero M.
Watkins Maren
Carlson Karen Cochrane
Cognetix, Inc.
Kosson Rosanne
Rothwell Figg Ernst & Manbeck P.C.
The University of Utah Research Foundation
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