α adrenergic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S332500

Reexamination Certificate

active

06919357

ABSTRACT:
Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men.wherein:R1is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6alkyl, C1-C6alkoxy, carboxy, amino, cyclohexyl, C1-C6alkylamino, or (C1-C6alkyl)2amino;R2is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6alkyl, C1-C6alkoxy, carboxy, amino, C1-C6alkylamino, or (C1-C6alkyl)2amino;R3is a group of the formulaR4is hydrogen or C1-C6alkyl;R5is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6alkyl, C1-C6alkoxy, carboxy, amino, C1-C6alkylamino, or (C1-C6alkyl)2amino; andR6is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6alkyl, C1-C6alkoxy, carboxy, amino, C1-C6alkylamino, or (C1-C6alkyl)2amino;or pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 5731339 (1998-03-01), Lowrey
J. of Urology vol. 159, 1214-16, 1998; Becker et al.; Oral Pentolamine as Treatment for Erectile Dysfunction.
Int. J. of Impotence Research vol. 6, 37-41, 1994, Zorgniotti, A.W.; Experience with Buccal Phentolamine Mesylate for Impotence.
J. of Sex and Marital Therapy, vol. 25, 137-144, 1999; Rosen et al.; Oral Phentolamine and Female Sexual Arousal Disorder.
Int. J. of Impotence Research, vol. 10, 215-223, 1998; Traish et al.; Phentolamine Mesylate Relaxes Penile Covpus Cavernosum Tissue by Adrenergic and Non-adrenergic Mechanisms.

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