α 4 β 2 δGABA-A receptors as a strategy...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C435S007100, C435S007200, C435S007210, C435S007500, C435S007920

Reexamination Certificate

active

07816074

ABSTRACT:
The present invention is directed to a screening mechanism for identifying members of the general population at increased risk for alcoholism and premenstrual syndrome. The screening mechanisms may be used to measure the expression of the α4β2δ GABAAreceptors, in order to identify members of the general population as having an increased sensitivity to lower concentrations alcohol coupled with a decrease sensitivity to higher concentrations of alcohol, a scenario frequently found in patients suffering from alcoholism and premenstrual anxiety. Methods of screening for drugs which decrease expression of the α4β2δ subunit of GABAAare also provided.

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patent: WO 96/10637 (1996-04-01), None
Borghese CM et al. Studies of ethanol actions on recombinant delta-containing GABA-A receptors yield contradictory results. Alcohol, May 2007; 41(3):155-162.
Feldman RS et al. Principles of Neuropsychopharmacology. 1997, Sinauer Associates, Inc., Publishers; Sunderland, MA; pp. 430-433.
Gault LM et al. NMDA receptor stimulation selectively initiates GABA-A receptor delta subunit mRNA expression in cultured rat cerebellar granule neurons. J. Neurochem. 1998; 70:1907-1915.
Smith S et al. a4b2d GABAA receptors exhibit a unique sensitivity to low concentrations of alcohol: Behavioral correlations in female rats. Meeting abstract from the 11th Congress of the International Society for Biomedical Research on Alcoholism. Alcoholism Clinical Exp Res. May 2002; 26(5 Suppl):16A, Abstract #65.
Sundstrom-Poromaa et al., (Jul. 2002), “Hormonally Regulated α4β2δ GABAAReceptors Are A Alcohol”,Nature Neuroscience5:8 721-722.

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