α-2/δ gene

Details α-2/δ gene α-2/δ gene

2007-08-28

2007-08-28

Andres, Janet L. (Department: 1647)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C530S412000, C536S023500

Reexamination Certificate

active

09787657

ABSTRACT:
The present invention relates to three novel genes and polypeptides derived therefrom encoding “α2δ-C” and/or “α2δ-D” proteins which exist as a subunit in many calcium channels. The invention also describes methods for using the novel gene and polypeptides in the detection of genetic deletions of the gene, subcellular localization of the polypeptide, binding assays in connection with chemical databases, gene therapy.

REFERENCES:
patent: 9504822 (1995-02-01), None
patent: 9811131 (1998-03-01), None
patent: 0012711 (2000-03-01), None
Myers, R.M. GenBank Accession No. G36524, Dec. 31, 1997.
Soares et al. GenBank Accession No. AA815447, Feb. 13, 1998.
Database EMBL 'Online!, AC AA190607, Hillier et al., 1997.
Database EMBL 'Online!, AC Z44942, Auffray et al., 1994.
Database EMBL 'Online!, AC R20288, Hillier et al., 1995.
Database EMBL 'Online!, AC AA459684, Hillier et al., 1994.
Database EMBL 'Online!, AC AC005343, Muzny et al., 1998.
Database EMBL 'Online!, AC AA719773, Hillier et al., 1998.
Database EMBL 'Online!, AC AA001473, Hillier et al., 1996.
Database EMBL 'Online!, AC Z75742, Wilkinson et al., 1996.
Database EMBL 'Online!, AC AB011130, Ohara et al., 1998.
Gee et al., “The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel”,The Journal of Biological Chemistry, vol. 271, No. 1, 1996, pp. 5768-5776.
Brown and Gee, “Cloning and Deletion Mutagenesis of the α2δ Calcium Channel Subunit from Porcine Cerebral Cortex”,The Journal of Biological Chemistry, vol. 273, No. 39, 1998, pp. 24458-25465.
Klugbauer et al., “Molecular Diversity of the Calcium Channel α2δ Subunit”,The Journal of Neuroscience, vol. 19, No. 2, 1999, pp. 654-691.
Williams et al., “Structure and Functional Expression of α1, α2, and β Subunits of a Novel Human Neuronal Calcium Channel Subtype”,Neuron, vol. 8, 1992, pp. 71-84.
Walker and De Waard, “Subunit interaction sites in voltage-dependent Ca2+channels: role in channel function”,Trends in Neurosciences, vol. 21, No. 4, 1998, pp. 148-154.

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